BU Research Blog

Aligning with BU’s 2025 Medical Science strategy and the proposed department of Medical Sciences, research findings to be published in Nature Communications describe a potential new target for the control of kidney failure in diabetics. BU (co-lead authorship), in collaboration with clinicians and scientists at the universities of Bristol, Edinburgh, Cambridge, Hong Kong, Toronto, Northwestern (Chicago), Otago in New Zealand, MRC Harwell and the pathology department in Glasgow (phew!), we have identified a metabolic signature in the kidney’s filtration cells (known as podocytes) that links insulin resistance to kidney failure. This is important because it details a mechanism which might be ‘tweaked’ in patients suffering from diabetic nephropathy – one of the most common causes of kidney failure in the world.

Paul S. Hartley.