BU Research Blog

The forensic science team at BU has been commissioned by the Home Office to evaluate an emerging threat to the U.K: ultra potent synthetic opioids. Our research has delivered a comprehensive chemical assessment of these dangerous drug compounds, evaluating differences between illicit drugs seized at borders versus inland, purity assessment, composition and variability, and headspace profiling to provide intelligence towards better detection of these drugs at borders. The work is led by Richard Paul, with co-investigators Ramin Boroujerdi, Sarah Upson, Santanu Majumder and Sam Rennie, all from the Life and Environmental Sciences department.

The illicit drug market has been dominated by the rise of fentanyl in North America in recent years, with a surge in drug related fatalities. The situation has now evolved with the emergence of non-fentanyl derived synthetic opioids, such as nitazenes, which are several times more potent than fentanyl, and can be as much as 500 times stronger than heroin. Urgent research is required to understand the nature of these drugs, and to provide intelligence to help detect these drugs when smuggled across borders.

Our analysis has shown that the purity of some of the nitazene compounds seized at borders is extremely high, with metonitazene and protonitazene at >98% pure. We’ve also developed a headspace analysis technique which examines the volatile molecules which comprise the odour profile of these drugs. This information is used to provide intelligence to the Home Office on which to base drug detection policy aimed at stopping the influx of these drugs into the U.K.  Our headspace technique revealed a complex array of aromatic organic compounds in the headspace above illicit nitazenes, and there is evidence that these compounds are used as precursors during illicit synthesis routes for these drugs.

This work is on-going and where possible we’ll post updates in the future. To find out more about the capabilities of our group, and other research we’re involved in, please see our group page here.