BU Research Blog

The 13th Annual Postgraduate Research Conference, hosted by the Doctoral College.

Jack Wieland (PhD, FST) with this poster entitled: Investigating the Role of Microsatellite Instability in Reproduction. 

Click the poster below to enlarge and you can listen to the accompanying audio.

Infertility is defined as the inability to conceive after 1 year without the use of birth control methods. Previous research has revealed that genetic analysis to date is strongly associated with different nucleotide pathogenic variants within different DNA repair systems. However, there is little understanding in how microsatellite instability and the role of the immune system contributing to infertility. The workflow presented shows how this conclusion was drawn using a self-designed MySQl database utilising the research published to date. The next step from this is to undertake laboratory and computational bioinformatic analysis to demonstrate how microsatellite instability contributes to infertility. Other future directions of this research may explore how other genomic abnormalities contribute to infertility that may have not been reported in research to date.

You can view the full poster exhibition and pre-recorded presentations on the conference webpage.

If this research has inspired you and you’d like to explore applying for a research degree please visit the postgraduate research web pages or contact the Doctoral College dedicated admissions team.