Tagged / clinical research

NIHR Grant Applications Seminar & Support Event – 26 June 2018

 

 

 

Are you planning to submit a grant application to NIHR?

We are holding a one-day event in Bournemouth that is aimed at helping you to improve your chances of success.

The morning seminar session is open to anyone to come and hear Simon Goodwin, RfPB Programme Manager for the South West, and RDS advisers give presentations on what makes a good grant proposal. Topics covered will include:

  • what does the NIHR (and in particular RfPB) look for?
  • the application as a marketing document: selling the topic, selling the method, and selling the team
  • the team
  • clarity of description and explanation
  • feasibility issues
  • identifying and avoiding potential pitfalls.

The afternoon support session of one-to-one appointments is for those who would like to discuss their own proposal with an RDS adviser.

This event is FREE and refreshments and lunch will be provided. Places are limited and will be allocated on a ‘first come, first served’ basis. In order to secure your place please register using our online form by 1pm, 18 June 2018Find out more.

And don’t forget, your local branch of the NIHR Research Design Service is based within the BU Clinical Research Unit (BUCRU) on the 5th floor of Royal London House. Feel free to pop in and see us, call us on 61939 or send us an email.

NIHR Grant Applications Seminar & Support event – last chance to book

 

 

 

 

Are you planning to submit a grant application to NIHR?

Research Design Service South West (RDS-SW) are holding a one day event on 9 November 2017 at Plymouth Science Park, Devon.

Last few days to book!

The events consists of:

  • a morning seminar session which is open to anyone to come and RDS advisers give presentations on what makes a good grant proposal.
  • an afternoon support session of one-to-one appointments which is for those who would like to discuss their own proposal with an RDS adviser. Those interested in this opportunity will be asked to supply in advance a brief description of their project idea.

Registration is FREE and lunch will be provided. Places are limited and will be allocated on a ‘first come, first served’ basis. In order to secure a place at one of these events, delegates will need to complete the online registration form by 1pm 30 October 2017. One-to-one appointments need to be booked in advance by selecting the appropriate option on the registration form.

You can find out more here

Don’t forget your local branch of the NIHR Research Design Service is based within the BU Clinical Research Unit (BUCRU) on the 5th floor of Royal London House. Feel free to pop in and see us, call us on 61939 or send us an email.

NIHR Fellowship Information Event – November 2017 – Book Now!

Are you interested in applying for an NIHR Fellowship?  Do you have questions? Need more info?

Information Event – 24 November 2017 – University of Exeter

There are many types of NIHR Fellowship award on offer, so how do you know which one is the best for you? When and how do you apply? What makes a good application? If you want to know more about NIHR Fellowships – and other NIHR training and career development awards – then this event is for you.

The morning session is open to anyone to come and hear from a number of speakers – from NIHR as well as existing panel members and award holders.

The afternoon support session of one-to-one appointments is for those who would like to discuss their own proposal with an RDS adviser.

See here for more information.
This event is FREE and refreshments and lunch will be provided. Places are limited and will be allocated on a ‘first come, first served’ basis. In order to secure your place please register using the online form by 1pm, 10 November 2017.

 

Your local branch of the NIHR Research Design Service is based within the BU Clinical Research Unit (BUCRU) on the 5th floor of Royal London House. Feel free to pop in and see us, call us on 61939 or send us an email.

NIHR Research Design Service Grant Writing Retreat

Do you have a great idea for research in health or social care?

Would your team benefit from protected time and expert support to develop your idea into a competitive funding application?

The Research Design Services South West (RDS SW) and South Central (RDS SC) are delighted to offer a unique opportunity to researchers in health and social care across their regions. to attend a week-long residential Grant Writing Retreat at Dillington House, near Ilminster in Somerset from Monday 4 September to Friday 8 September 2017 inclusive. The purpose of the Retreat is to give busy professionals dedicated time to rapidly progress their research idea into fundable proposals. The Retreat will provide a supportive environment for research teams to develop high quality research proposals prior to application to national peer-reviewed funding streams. Participating teams will enjoy protected time dedicated to the development of their research proposals away from the distractions of their workplace, expert help and support from RDS adviser staff and the experience of working as part of a professional research team.

I urge you and your colleagues to have a look at the website to find out more details, the process for applying for a place on the retreat, and examples of success stories: http://rds-sw.nihr.ac.uk/rgwr.htm

The cost of the retreat is £2,850 per team of three researchers (see website for details). The opportunity to apply is open to everyone across our region.

HOWEVER, for teams that successfully apply for a place on the retreat, and that consist of at least one member of staff from the Department of Nursing and Clinical Sciences here at BU, the University can offer a limited number of places funded by the Department (2 but might be able to stretch to more).   If you don’t have anybody in mind within the department but still interested in collaborating and applying for a free space offered by the university please contact us and we can facilitate this and try to find people with shared interests and ideas.

Applications for the retreat must be submitted to RDS by 1pm 26th April 2017, and it is important that you discuss your application with someone from the BUCRU/RDS team at an early stage (Sarah Thomas, Helen Allen, Sharon Docherty, Andy Powell, Peter Thomas).

Your local branch of the NIHR Research Design Service is based within the BU Clinical Research Unit (BUCRU) on the 5th floor of Royal London House. Feel free to pop in and see us, call us on 61939 or send us an email.

Bournemouth University Clinical Research Unit 2017 Newsletter Now Available

bucru identity

The latest newsletter from the Bournemouth University Clinical Research Unit (BUCRU) is available to download here. Take a look at the successful grant applications we were involved in last year, and what else we got up to in 2016. There is also an update from our colleagues in the Centre of Post Graduate Medical Research and Education (CoPMRE).

Don’t forget, BUCRU can provide FREE methodological advice and support in designing your research project. We’re based on the 5th floor of Royal London House so feel free to pop in and see us, call us on 61939 or send us an email.

BUCRU – Seminar presenting Breaking News!

 

BREAKING  NEWS…

We would like to invite you to an afternoon seminar by one of our Visiting Faculty, Professor Mike Wee, presenting some exciting new research findings to come out of a recently completed Research for Patient Benefit funded study comparing two methods of pain relief during labour (abstract and biography below).  This paper was just voted best paper of the conference at the Obstetric Anaesthetists Association Annual Conference in Liverpool and was featured recently in the Bournemouth Echo http://www.bournemouthecho.co.uk/news/9770928.Pain_relief_in_labour__study_at_Poole_hospital_makes_important_discovery/

The seminar is scheduled for Thursday 19th July 2-3pm in BG10 Bournemouth House (after the HSC end of term lunch and next door for your convenience).

We hope you can make it and look forward to seeing you then.

BUCRU

Website: http://microsites.bournemouth.ac.uk/bucru/

Administrator: +44 (0)1202 961939 / wardl@bournemouth.ac.uk

Title: The IDvIP Trial: A two-centre double blind randomised controlled trial comparing i.m. diamorphine and i.m. pethidine for labour analgesia

Research team and affiliations: MYK Wee, JP Tuckey,* P Thomas,† S Burnard,* D Jackson.

Poole Hospital NHS Foundation Trust, Poole, UK, *Royal United Hospital, Bath, UK, Bournemouth University Clinical Research Unit, Bournemouth, UK.

Abstract:

Background: Intramuscular pethidine, the commonest parenteral opioid analgesic used in obstetrics and more recently diamorphine usage has increased in the UK.  The maternal, fetal and neonatal side effects are well known for pethidine but there are no sufficiently powered large RCTs comparing pethidine with diamorphine. The aim of this trial is to address this.

Methods: After ethical approval, informed consent was obtained from 484 women randomised to receive either 7.5mg diamorphine i.m. or 150mg pethidine i.m. for labour analgesia. The sample size calculation derived from a small RCT giving 90% power (at the 5% significance level) is based upon the maternal primary outcome measure of pain relief at 60mins and the neonatal primary outcome measures of Apgar Score of <7 at 1min and neonatal resuscitation. Secondary outcome measures include verbal pain intensity at 60mins and over 3hrs post-analgesia, pain relief over first 3hrs, maternal oxygen saturation, sedation, nausea and vomiting and maternal satisfaction with analgesia. Fetal and neonatal secondary outcomes include CTG trace, meconium staining, UApH, UVpH, time of delivery to first breath, Apgar Score at 5mins, naloxone use, neonatal oxygen saturations, sedation and feeding behaviour for the first 2hrs after delivery.

Results: Reported using CONSORT guidelines. At 60mins post-administration and over a 3hr period, diamorphine is better at reducing pain scores than pethidine (p<0.001). There were no statistical differences between the two groups regarding Apgar Scores of <7 at 1min and the need for neonatal resuscitation.  The time between first dose administered and delivery is on average 82mins longer with the diamorphine group compared to pethidine (p<0.001). The vast majority of women experienced moderate to severe pain at all times. Women receiving diamorphine were more satisfied with their analgesia. There were no statistically significant differences in maternal sedation, nausea and vomiting or oxygen saturations over the 3hr period. There were no statistically significant differences in the fetal and neonatal outcomes including feeding behaviour between the two groups within 2hrs of birth but neonates in the pethidine group were more likely to be moderately or severely sedated at delivery.

Discussion: Intramuscular 7.5mg diamorphine gives significantly better analgesia than 150mg pethidine but prolongs delivery by approx. 82mins.  Women given diamorphine are more likely to be satisfied with their analgesia.  The mechanism for the prolongation of delivery time in the diamorphine group should be investigated further.

Acknowledgement: This research was funded by the NIHR Research for Patient Benefit Programme (PB-PG-0407-13170).

References

1. Tuckey JP, Prout RE, Wee MYK. Prescribing intramuscular opioids for labour analgesia in consultant-led maternity units: a survey of UK practice. International Journal of Obstetric Anesthesia 2008, 17(1):3-8.

2. Fairlie FM, Marshall L, Walker JJ et al. Intramuscular opioids for maternal pain relief for labour: a randomised controlled trial comparing pethidine with diamorphine. British  Journal of Obstetrics and Gynaecology 1999; 106(11): 1181 -1187.

Biography of speaker:

Michael Wee is a consultant anaesthetist from Poole Hospital and Royal Bournemouth Hospitals.  He has a special interest in obstetric anaesthesia and is the lead obstetric anaesthetist at Poole Hospital.  He is chair of the Research and Innovations Group at Poole Hospital and is a Board member of the Western Comprehensive Local Research Network.  He was awarded a visiting professorship at Bournemouth University in 2009.  He is a referee for several medical journals.  His research interests include patient information, safety in anaesthesia, maternal analgesia and simulation in epidural anaesthesia.  He is a co-supervisor of a PhD student at BU and chief investigator of the MObs study investigating early warning scores in obstetrics.

Bournemouth University Clinical Research Unit (BUCRU) Consultancy Service

What is the Consultancy Service?

BUCRU has developed a consultancy service aimed at organisations that have an interest in health and wellbeing. Members of the team have many years experience of providing consultation services to the NHS, public bodies, charities and businesses. In addition to research projects we can also advise on audit projects, clinical evaluations, service evaluations and other areas where the collection and analysis of good quality data is important.

How can it help?

The service is flexible and tailored to the client’s requirements. Typically an initial meeting will involve finding out about the client’s needs and discussing the ways in which we can help. Our involvement could range from a single meeting to discuss a particular issue, through to conducting a project on behalf of the client.

Some examples are:

¨                  Advising on or conducting clinical trials, surveys, epidemiological studies, pilot and feasibility studies

¨                  Study design

¨                  Advice on sample size

¨                  Questionnaire design and validation

¨                  Outcome measures

¨                  Data collection and management

¨                  Statistical analysis and interpretation

¨                  Qualitative and mixed methods approaches

¨                  Design and evaluation of complex interventions such as found in medicine, psychology, nursing, physiotherapy and so on.

¨                  Managing and running studies

¨                  Advice on ethics and governance approval processes.

¨                  Involving patients and the public in research

¨                  Troubleshooting

How do I find out more?

For further information about, and access to, our consultancy service please contact:

Louise Ward (administrator):

Bournemouth University Clinical Research Unit

R505 Royal London House

Christchurch Road

Bournemouth BH1 3LT

BUCRU@bournemouth.ac.uk

Tel: 01202 961939

http://blogs.bournemouth.ac.uk/bucru/

Research within the Bournemouth University Clinical Research Unit (BUCRU)

In previous blogs we have described how BUCRU can help in developing grant applications. In this blog we describe some of the funded projects we are involved in.

BUCRU led research

Fatigue management in multiple sclerosis (MS):  We have just completed a multi-centre randomised trial of a cognitive behavioural approach to fatigue management in people with multiple sclerosis1. This project was funded by the MS Society (http://www.mssociety.org.uk).

Improving activity and wellbeing in people with MS: We are just starting a MS Society funded pilot study to look at the Nintendo Wii home gaming system as a method of helping people with MS increase their activity levels and wellbeing.

Systematic review of psychological interventions for people with MS: A small grant to update our existing Cochrane review2

BUCRU collaborative projects

IDvIP: A National Institute for Health Research (NIHR) Research for Patient Benefit (RfPB) (http://www.ccf.nihr.ac.uk/RfPB/Pages/home.aspx) funded project. This is a multi-centre trial comparing 2 methods of pain relief for women in labour; diamorphine and pethidine3. The Chief Investigator is a Consultant in one of the local hospitals and a member of the Bournemouth University Visiting Faculty. BUCRU staff were involved in the design of the study, applying for the grant, data management, statistical analysis and interpretation, and advice on project management.*

WEIGHTED: A small grant from the College of Emergency Medicine held by a local Consultant/ member of the Visiting Faculty. This study is about to start and aims to develop a robust method of estimating the weight of patients attending a hospital emergency department. Many patients require a weight dependent dose of potentially life saving medication, but are too ill to be actually weighed.  BUCRU were involved in designing the study and securing funding, and will be involved in ongoing advice on project and data management, statistical analysis and interpretation.

PEARLS: A large multi-centre trial of training maternity staff in assessing and repairing tears to the perineum acquired during labour and delievery4. This project is funded by the Health Foundation (http://www.health.org.uk) and run under the auspices of the Royal College of Midwives. BUCRU has been involved in data management, statistical analysis and interpretation.

PREVIEW: A pilot randomised trial comparing two methods of looking after tears to the perineum. The Chief Investigator is based in Birmingham, and the study is funded by the NIHR RfPB funding scheme. This study has recently started, and BUCRU was involved in the design of the study and the funding application. Further involvement will be in advising on project management, data management and statistical analysis.

Clinical Doctoral Research Fellowship: (http://www.nihrtcc.nhs.uk). Award held by BU and won by a radiographer based at the Anglo-European College of Chiropractic. The project involves tracking and measuring spinal motion. The research may have important implications in diagnosing people with chronic lower back pain. BUCRU were involved in the study design and funding application, and 2 members of staff are supervisors for her PhD.

Contact us:

In the first instance please contact

Louise Ward (administrator):

Bournemouth University Clinical Research Unit

R505 Royal London House

Christchurch Road

Bournemouth BH1 3LT

BUCRU@bournemouth.ac.uk

Tel: 01202 961939

 http://blogs.bournemouth.ac.uk/bucru/

1 Thomas, P.W., Thomas, S., Kersten, P., Jones, R., Nock, A., Slingsby, V., et al., 2010. Multi-centre parallel arm randomised controlled trial to assess the effectiveness and cost-effectiveness of a group-based cognitive behavioural appoach to managing fatigue in people with multiple sclerosis. BMC Neurology, 10:43

2 Thomas, P.W., Thomas, S., Hillier, C., Galvin, K., and Baker, R. (2006). Psychological interventions for multiple sclerosis. The Cochrane Database of Systematic Reviews (Vol. Issue 1, pp. Issue 1. Art. No.: CD004431. DOI: 10.1002/14651858.CD004431.pub2): John Wiley and Sons, Ltd.

3 Wee, M.Y.K., Tuckey, J.P., Thomas, P., Burnard, S. 2011. The IDvIP Trial: A two-centre randomized double-blind controlled trial comparing intramuscular diamorphine and intramuscular pethidine for labour analgesia. BMC Pregnancy and Childbirth, 11: 51

4 Bick, D.E., Kettle, C., MacDonald, S., Thomas, P.W., Hill, R.K., Ismail, K.. 2010. PErineal Assessment and Repair Longitudinal Study (PEARLS): protocol for a matched pair cluster trial. BMC Pregnancy and Childbirth, 10:10.

Bournemouth University Clinical Research Unit (BUCRU) Events and Services

BUCRU incorporates the Dorset Office of the National Institute for Health Research (NIHR) Research Design Service – South West (RDS-SW). This means that in addition to the support outlined in previous blogs, we can also provide access to the following:

RDS Grant application workshop.

This workshop is going to be held at Bournemouth University on the 29th February 2012 (http://www.rds-sw.nihr.ac.uk/grant_workshop.htm). Although the official deadline for applying has recently passed, it is worth contacting us to see if there are any remaining places. The workshop will also be held in other locations in the South-West region in the near future.

This is a one-day workshop for researchers who are developing proposals with the intention of applying for a grant. The workshop does not provide detailed training in research methodology; rather it more generally covers the full range of issues inherent in developing a successful grant application. It will be of relevance to researchers applying to any of the major health research funders, but particularly the NIHR funding schemes.

Researchers will need to send in advance the latest draft of their research proposal. As a minimum they should have a plan for a project but, ideally, a worked up proposal, perhaps even one that has been previously rejected. All proposals will receive detailed written feedback from the RDS team.

Topics include

  • The application as a marketing document, selling the topic, selling the method, and selling the team;
  • The balanced team;
  • Clarity of description and explanation;
  • Feasibility issues;
  • Identifying and avoiding potential pitfalls

 

RDS Residential Research Retreat

The Residential Research Retreat (http://www.rds-sw.nihr.ac.uk/rrr_home.htm) provides an opportunity for research teams to develop high quality health related research proposals suitable for submission to national peer-reviewed funding schemes. The aim of the Retreat is to provide the environment and support to promote rapid progress in developing proposals over a relatively short time period.

This Research Retreat is open to health professionals and academics working within the South West. Applications to attend the Retreat should be submitted by a team of three people with varied skills. Applications are reviewed competitively and places awarded to the most promising team proposals. The deadline for the next Research Retreat has passed, but it is anticipated that applications will be invited again later in the year.  

At the retreat participants are supported by a range of experts while developing their research proposal. They work intensively on their proposal, while learning how to maximise its chances for successfully securing a grant.

In addition, the Residential Research Retreat helps participants develop the key skills needed to conduct research in a clinical setting as well as nurturing presentation skills and giving them the confidence to tackle research problems. 

 

RDS Scientific Committee

The RDS Scientific Committee (http://www.rds-sw.nihr.ac.uk/scientific_committee.htm) provides an excellent opportunity for researchers in the south-west to obtain a critical review of a proposed grant application before it is sent to a funding body. The Committee brings the benefit of seeing the proposal with “fresh eyes”, replicating as far as possible the way the real funding committee will consider the application. Committee members include senior research consultants who have considerable experience of obtaining research funding, resulting in comprehensive comments and advice fed back.

Committee meetings take place approximately 9 times per year. To submit a study for review at the meeting, study paperwork must be provided to the Committee via BUCRU two weeks prior to the meeting date, and preferably a couple of months before the intended funding deadline.

 

Centre of Postgraduate Medical Research and Education (CoPMRE) Annual Symposium

In addition to events aimed at supporting the development of grant applications we also host an event geared towards dissemination. The CoPMRE Annual Symposium will be held on the 11th September 2012 at the Bournemouth University Talbot Campus. These successful annual conferences have been running for the past nine years and have featured themes such as ‘Professionalism and Collaboration’, ’Research Innovation’ and ‘Interprofessional Learning’. This year’s theme will be on using ‘Social media techniques in healthcare research and education’.  The conference is open to all healthcare professionals and academics.  More information will be posted on our website in due course and you will be able to register online nearer the time.  For further information on the symposium please contact Audrey Dixon, Conference Manager (adixon@bournemouth.ac.uk ).

Contact us: For further information about, and access to, the Grant applications workshop, the Residential Research Retreat and the Scientific Committee please contact:

Louise Ward (administrator):

Bournemouth University Clinical Research Unit

R505 Royal London House

Christchurch Road

Bournemouth BH1 3LT

BUCRU@bournemouth.ac.uk

Tel: 01202 961939

http://blogs.bournemouth.ac.uk/bucru/