Tagged / heart

Molecular basis for a healthier heart…new work published by BU

Research funded by the British Heart Foundation looking at tissue fibrosis (scarring), will soon be published in Experimental Gerontology, one the world’s leading journal on ageing. Fibrosis occurs naturally as part of our injury response process but also develops in ageing and chronic disease. Treatments are scant despite fibrosis leading to organ failure and increased risk of death.

The image shows valves (v) in the hearts of young and ‘late middle aged’ fruit flies that have been genetically engineered to express fluorescent collagen, an key ‘scar protein’. Although the fly heart is just two cells wide it represents a lot of the genetic machinery for a human heart. Amazingly, the function of human and fly hearts declines as they age – and they both accumulate collagen.

Our previous work linked heart function with SPARC – a protein associated with fibrosis in humans.  We’ve now demonstrated that the heart’s ‘health-span’ during ageing can be significantly lengthened if the expression SPARC is reduced. We also show that if SPARC levels increase – fibrosis is increased too. Hence, we’ve nailed a cause-and-effect relationship between SPARC and heart function which supports the idea of targeting SPARC clinically to control cardiac health and fibrosis.

Paul S. Hartley (Department of Life and Environmental Science).

Best paper award!

Heart 2015Best Paper for 2015 Award in the international journal Heart.  A paper published by Bournemouth University PhD student, Edward Carlton,  and his supervisors, Prof. Ahmed Khattab (FHSS) and Prof. Kim Greaves from the University of the Sunshine Coast in Australia in collaboration with world-renowned hospitals: John Radcliffe Hospital in Oxford; Royal Brisbane & Women’s Hospital in Australia; and Christchurch Hospital in New Zealand has  been announced as the Winner of the “Heart Best Paper 2015  Award” [1].  This award is in recognition of the high quality and clinical impact of the paper. The winner for this award were chosen by the Editorial Team from the top 10 papers in each of the following three categories: downloads, citations and Altmetrics Score.

Dr. Edward Carlton has just finished his PhD at BU and he is now working as an Emergency Medicine Consultant in Bristol.Heart PDF 2015

Congratulations!

Prof. Edwin van Teijlingen

CMMPH

 

 

Reference:

Carlton EW, Cullen L, Than M, Gamble J, Khattab A, Greaves K. A novel diagnostic protocol to identify patients suitable for discharge after a single high-sensitivity troponin. Heart. 2015 Jul;101(13):1041-6. doi: 10.1136/heartjnl-2014-307288. Epub 2015 Feb 17.