Tagged / cochrane review

Congratulations to Heidi Singelton & Steve Ersser

Publishing, writing

In late August Heidi Singleton led the publication of a Cochrane Systematic Review under the title ‘Educational and psychological interventions for managing atopic dermatitis (eczema)’ [1].  The team conducting this review includes BU’s Prof. Steve Ersser, University Hospitals Dorset NHS Foundation Trust colleagues Dr. Andrew Hodder, former BU staff Prof. Vanessa Heaslip (currently at the University of Salford), and one of my co-authors on a previous project Dr. Dwayne Boyers from the Health Economics Research Unit at the University of Aberdeen.

In their review the authors conclude that in-person, individual education, as an adjunct to conventional topical therapy, may reduce short-term eczema signs compared to standard care, but there is no information on eczema symptoms, quality of life or long-term outcomes. Group education probably reduces eczema signs and symptoms in the long term and may also improve quality of life in the short term. Favourable effects were also reported for technology-mediated education, habit reversal treatment and arousal reduction therapy. All favourable effects are of uncertain clinical significance, since they may not exceed the minimal clinically important difference (MCID) for the outcome measures used.  Finally, they found no trials of self-help psychological interventions, psychological therapies or printed education. Future trials should include more diverse populations, address shared priorities, evaluate long-term outcomes and ensure patients are involved in trial design.

 

Well done!

Prof. Edwin van Teijlingen

CMWH

Reference:

  1. Singleton, H., Hodder, A., Almilaji, O., Ersser, S. J., Heaslip, V., O’Meara, S., Boyers, D., Roberts, A., Scott, H., Van Onselen, J., Doney, L., Boyle, R. J., & Thompson, A. R. (2024). Educational and psychological interventions for managing atopic dermatitis (eczema). The Cochrane database of systematic reviews, 8(8), CD014932. https://doi.org/10.1002/14651858.CD014932.pub2

Research within the Bournemouth University Clinical Research Unit (BUCRU)

Funding opportunities

In previous blogs we have described how BUCRU can help in developing grant applications. In this blog we describe some of the funded projects we are involved in.

BUCRU led research

Fatigue management in multiple sclerosis (MS):  We have just completed a multi-centre randomised trial of a cognitive behavioural approach to fatigue management in people with multiple sclerosis1. This project was funded by the MS Society (http://www.mssociety.org.uk).

Improving activity and wellbeing in people with MS: We are just starting a MS Society funded pilot study to look at the Nintendo Wii home gaming system as a method of helping people with MS increase their activity levels and wellbeing.

Systematic review of psychological interventions for people with MS: A small grant to update our existing Cochrane review2

BUCRU collaborative projects

IDvIP: A National Institute for Health Research (NIHR) Research for Patient Benefit (RfPB) (http://www.ccf.nihr.ac.uk/RfPB/Pages/home.aspx) funded project. This is a multi-centre trial comparing 2 methods of pain relief for women in labour; diamorphine and pethidine3. The Chief Investigator is a Consultant in one of the local hospitals and a member of the Bournemouth University Visiting Faculty. BUCRU staff were involved in the design of the study, applying for the grant, data management, statistical analysis and interpretation, and advice on project management.*

WEIGHTED: A small grant from the College of Emergency Medicine held by a local Consultant/ member of the Visiting Faculty. This study is about to start and aims to develop a robust method of estimating the weight of patients attending a hospital emergency department. Many patients require a weight dependent dose of potentially life saving medication, but are too ill to be actually weighed.  BUCRU were involved in designing the study and securing funding, and will be involved in ongoing advice on project and data management, statistical analysis and interpretation.

PEARLS: A large multi-centre trial of training maternity staff in assessing and repairing tears to the perineum acquired during labour and delievery4. This project is funded by the Health Foundation (http://www.health.org.uk) and run under the auspices of the Royal College of Midwives. BUCRU has been involved in data management, statistical analysis and interpretation.

PREVIEW: A pilot randomised trial comparing two methods of looking after tears to the perineum. The Chief Investigator is based in Birmingham, and the study is funded by the NIHR RfPB funding scheme. This study has recently started, and BUCRU was involved in the design of the study and the funding application. Further involvement will be in advising on project management, data management and statistical analysis.

Clinical Doctoral Research Fellowship: (http://www.nihrtcc.nhs.uk). Award held by BU and won by a radiographer based at the Anglo-European College of Chiropractic. The project involves tracking and measuring spinal motion. The research may have important implications in diagnosing people with chronic lower back pain. BUCRU were involved in the study design and funding application, and 2 members of staff are supervisors for her PhD.

Contact us:

In the first instance please contact

Louise Ward (administrator):

Bournemouth University Clinical Research Unit

R505 Royal London House

Christchurch Road

Bournemouth BH1 3LT

BUCRU@bournemouth.ac.uk

Tel: 01202 961939

 http://blogs.bournemouth.ac.uk/bucru/

1 Thomas, P.W., Thomas, S., Kersten, P., Jones, R., Nock, A., Slingsby, V., et al., 2010. Multi-centre parallel arm randomised controlled trial to assess the effectiveness and cost-effectiveness of a group-based cognitive behavioural appoach to managing fatigue in people with multiple sclerosis. BMC Neurology, 10:43

2 Thomas, P.W., Thomas, S., Hillier, C., Galvin, K., and Baker, R. (2006). Psychological interventions for multiple sclerosis. The Cochrane Database of Systematic Reviews (Vol. Issue 1, pp. Issue 1. Art. No.: CD004431. DOI: 10.1002/14651858.CD004431.pub2): John Wiley and Sons, Ltd.

3 Wee, M.Y.K., Tuckey, J.P., Thomas, P., Burnard, S. 2011. The IDvIP Trial: A two-centre randomized double-blind controlled trial comparing intramuscular diamorphine and intramuscular pethidine for labour analgesia. BMC Pregnancy and Childbirth, 11: 51

4 Bick, D.E., Kettle, C., MacDonald, S., Thomas, P.W., Hill, R.K., Ismail, K.. 2010. PErineal Assessment and Repair Longitudinal Study (PEARLS): protocol for a matched pair cluster trial. BMC Pregnancy and Childbirth, 10:10.