Tagged / polyunsaturated fatty acids

New publication on essential fatty acids in donor human milk in the UK

PG research

Congratulations to FHSS PhD student Isabell Nessel who published part of her integrated PhD thesis in the Journal for Parenteral and Enteral Nutrition last week.

The paper “Long‐Chain Polyunsaturated Fatty Acids and Lipid Peroxidation Products in Donor Human Milk in the United Kingdom: Results From the LIMIT 2-Centre Cross-Sectional Study” resulted from a collaboration between BU (Isabell Nessel, Prof Jane Murphy, Dr Simon Dyall – now at the University of Roehampton), Poole Hospital NHS Foundation Trust (Prof Minesh Khashu), and St. George’s University Hospitals NHS Foundation Trust (Dr Laura De Rooy) (1). Full text can be found here: https://onlinelibrary.wiley.com/doi/full/10.1002/jpen.1773

This paper shows for the first time that donor human milk in the UK has very low levels of essential fatty acids, which are important for brain and eye development. Furthermore, donor human milk has higher lipid degradation than preterm and term breast milk. This could have important implications for preterm infant nutrition as exclusive unfortified donor human milk feeding might not be suitable long term and may contribute to the development of major neonatal morbidities.

This study followed from a narrative review Isabell and her supervisors Prof Minesh Khashu and Dr Simon Dyall published last year, which suggested that current human milk banking practices might have detrimental effects on essential fatty acid quality and quantity in donor human milk (2).

Isabell

inessel@bournemouth.ac.uk

Reference

  • Nessel, Isabell, et al. “Long‐Chain Polyunsaturated Fatty Acids and Lipid Peroxidation Products in Donor Human Milk in the United Kingdom: Results From the LIMIT 2‐Centre Cross‐Sectional Study.” Journal of Parenteral and Enteral Nutrition(2020).
  • Nessel, Isabell, Minesh Khashu, and Simon C. Dyall. “The effects of storage conditions on long-chain polyunsaturated fatty acids, lipid mediators, and antioxidants in donor human milk–a review.” Prostaglandins, Leukotrienes and Essential Fatty Acids(2019).

BU research into breast milk quality-Participants needed

PG research

 

We are looking for breast feeding mums to donate 5 mL of breast milk for a research study conducted at BU.

When mother’s own milk is not sufficient or appropriate, preterm babies can be fed with donor milk from a human milk bank. However, the processes used in milk banking might increase the risk of fat degradation in the milk. Currently, nothing is known about fat degradation products in donor milk. With this study, we aim to quantify fat degradation products in donor milk, and we are currently looking for some term breast milk to compare our results to.

If you are breastfeeding and would like to take part in the study, please get in touch!

Please feel free to share the information with any breastfeeding mum you know!

If you want to know more about milk banking in the UK, read my earlier blog post here.

Many thanks, Isabell

inessel@bournemouth.ac.uk

01202965009

BU research into breast milk quality-Participants needed

PG research, student research

 

We are looking for breast feeding mums to donate 5 mL of breast milk for a research study conducted at BU.

When mother’s own milk is not sufficient or appropriate, preterm babies can be fed with donor milk from a human milk bank. However, the processes used in milk banking might increase the risk of fat degradation in the milk. Currently, nothing is known about fat degradation products in donor milk. With this study, we aim to quantify fat degradation products in donor milk, and we are currently looking for some term breast milk to compare our results to.

If you are breastfeeding and would like to take part in the study, please get in touch!

Please feel free to share the information with any breastfeeding mum you know!

If you want to know more about milk banking in the UK, read my earlier blog post here.

Many thanks, Isabell

inessel@bournemouth.ac.uk

01202965009

BU’s PGR student Isabell Nessel has been awarded New Investigator Award and will be presenting at the 13thCongress of the International Society for the Study of Fatty Acids and Lipids (ISSFAL)

PG research

The 13th Congress of the International Society for the Study of Fatty Acids and Lipids (ISSFAL) http://www.issfal.org/ will be held in Las Vegas, USA in May 2018. BU will be highly represented at this biennial congress, which is the biggest and most prestigious congress in the field of fatty acid and lipid research. Isabell Nessel, a third year PhD student in the Faculty of Health and Social Sciences, will present her PhD work at this congress. She is supervised by Dr Simon Dyall and Prof Minesh Khashu.

Her research aims to investigate ways to increase the intake of long-chain polyunsaturated fatty acids in the perinatal period and to address whether this intake is associated with any adverse effects, due to the susceptibility of the fatty acids to oxygen-related damage. Isabell secures a prestigious oral presentation, and is also presenting two posters at this international congress, which expects around 800 delegates!

Isabell was awarded a full Santander Mobility Award to cover the travel costs to Las Vegas. Furthermore, Isabell won a New Investigator Award, which is granted by ISSFAL in conjunction with the Congress to recognise and encourage excellent abstract submissions.

The Congress will be an excellent opportunity for her to present her PhD work, and to learn about the latest research and the newest methods.

Isabell would like to express her gratitude to Santander, ISSFAL, and Bournemouth University for making this trip possible, and to her supervisors Dr Simon Dyall and Prof Minesh Khashu for their support with the applications and abstracts!

 

Look out for her blog post after the conference.

If you would like to know more about her research in the meantime, e-mail her at inessel@bournemouth.ac.uk

BU’s PGR Paul Fairbairn at the Lipids and Brain IV conference in Nancy

Knowledge Exchange, PG research, student research

The Société Française pour l’Etude des Lipides (SFEL) recently held the fourth iteration of their Lipids and Brain conference in Nancy France.

I was given the opportunity to present some preliminary results from an ongoing study I am conducting as part of my PhD, looking into the effects of a multi-nutrient omega-3 fatty acid supplement and exercise on mobility and cognitive function in ladies aged 60+.  Analysis of the baseline data revealed relationships between levels of omega-3 fatty acids in the blood with cognitive and gait outcomes, however this effect differed between non-frail and pre-frail participants.

The conference brought together scientists, physicians and nutritionists to provide a unique prospective on the role of lipid nutrition in the prevention and treatment of neurodegenerative diseases with a large focus on Alzheimer’s Disease (AD).  The conference was a mix of lectures, invited reviews, and poster sessions.  There was a tremendous variety of topics presented, including lectures on the pathophysiology and epidemiology of AD, how AD can impact lipid metabolism and the effects of lipid intake on prevention and treatment of AD.

During the conference Professor Stephen Cunnane from the Research Center on Aging, Sherbrooke (Canada) was presented with the prestigious Chevreul Medal.

On a personal note this was an exciting opportunity for me to present my work and represent Bournemouth University and my supervisory team of Dr. Simon Dyall and Dr. Fotini Tsofliou at a respected conference.  It was very satisfying to see some interest in my work from researchers whose work I myself look up to.

I would like to extend my gratitude towards Bournemouth University, for providing the funding that allowed me to attend the conference and to the scientific committee at the SFEL for organising such an impeccable event.

If you would like to learn more about our research, please feel free to contact me at pfairbairn@bournemouth.ac.uk

 

BU’s PGR Isabell Nessel at the Department of Life Sciences, University of Roehampton

PG research

 I had the pleasure of spending the last three weeks in the Department of Life Sciences (University of Roehampton), working with Dr Giulia Corona and Dr Volker Behrends. We successfully validated an ultra-high performance liquid chromatography coupled with triple quadrupole mass spectrometry (UPLC-MS/MS) method to analyse lipid peroxidation products (breakdown products of fats) in human urine samples.

Our ultimate goal is to identify the time-course of oxidative stress and subsequent breakdown of lipids in neonates, by analysing urinary lipid peroxides, to facilitate evidence-based approaches to antioxidant support in preterm neonates. My supervisors Dr Simon Dyall and Prof Minesh Khashu and I are currently developing a pilot study in cooperation with Poole Hospital NHS Foundation Trust to test the feasibility of measuring these products in urine samples from preterm neonates. However, before moving on to preterm samples, the method had to be tested and validated, using adult urine samples.

The project was made possible by an HSS Seed Corn fund obtained by Dr Simon Dyall, the PGR fund of Isabell Nessel, the collaboration with Dr Giulia Corona and Dr Volker Behrends at the Department of Life Sciences (University of Roehampton) and collaboration with Dr Thierry Durand and his group from the Institute des Biomolecules Max Mousseroux, (Montpellier, France) who generously provided the standards used in this analysis. I am grateful that I had this opportunity to further develop my research skills and to learn a new state-of-the-art technique and would like to thank all involved for making this possible!

If you would like to learn more about our research please feel free to contact me at inessel@bournemouth.ac.uk

Isabell

Fundraising for the Hearts Milk Bank at BU

PG research, student research

On the 17th of November, The World Prematurity Day, there was a fundraising cake sale for the Hearts Milk Bank.

cake-saleThe amount raised will help to either

– feed 14 babies for a day

–  or feed 3 babies for 5 days, the average time they need donor milk

– or buy enough containers for 55 mums to start donating milk

– or buy almost 3  transportation bags.

The Hearts Milk Bank is therefore 1 step closer to provide donor milk for babies born too soon or too sick!

 

I would like to thank anyone who has made this cake sale possible, the bakers and the buyers, the great people who donated money, SUBU, and the people helping me on the day. You are awesome!

Gillian Weaver, co-founder of the bank contacted me to say “We are so grateful to you Isabell and to everyone who supported your cake sale on World Prematurity Day. You raised a fantastic amount and we will put it to very good use helping to ensure that all premature and sick babies get access to safe and assured supplies of donor milk irrespective of where they are born in the UK. We know that this not only helps to prevent tiny babies from life threatening illnesses but also supports their mothers whilst they build up their own breastmilk supply. The Hearts Milk Bank (the bank with a difference) will also be a biobank of breastmilk samples for much needed research into breast cancer so your support for us is doubly valuable!”

ukamb_logo2If you would like to learn more about donor milk visit the website of the UK Association for Milk Banking.

gkjo6pcssbgobqmecfa6If you would like to learn more about the Hearts Milk Bank or would like to donate, please click here: https://www.indiegogo.com/projects/hearts-milk-bank-saving-tiny-babies-helping-mums-cancer

 

I learned about donor milk as part of my PhD thesis at BU, focusing on the effects of omega-3 and omega-6 fatty acids in the perinatal period. If you are interested in our research please contact me at inessel@bournemouth.ac.uk

Many thanks, Isabell

World Prematurity Day – 17th November – Cake Sale

PG research, student research

Would you donate a cake/cupcakes?

 

picture3Date:   17th November

Time:   11.30-13.30

  Venue: BoHo Lounge, Ground floor, Bournemouth House

Cake drop off on the morning of the 17th in R304 or B112a

 

picture1Preterm born babies are at high risk to develop a wide range of complications.

Some of these complications can be prevented by feeding babies with human breast milk.

Therefore, the WHO recommends human donor milk as best alternative if mother’s own milk is not available!

 

picture2The HEARTS MILK BANK is currently crowd funding to buy the needed equipment to start providing donor milk for babies born too soon or too sick, to improve their chance of survival and health!

All money from the cake sale will be directly donated to the Hearts Milk Bank!

 

 

If you want to donate a cake or receive  more information please contact

Isabell Nessel inessel@bournemouth.ac.uk

 

 

BU’s PhD Isabell Nessel at the Human Milk Bank in Southampton, Princess Anne Hospital

PG research, student research

human-milk-bank-southamptonMost of you have probably heard/read about human milk banking by now from me or my previous posts, if not read here more about it. This week, I had the opportunity to meet Anita Holloway-Moger, the Human Milk Bank Nursery Nurse at the Princess Anne Hospital Human Milk Bank in Southampton.

It was a great opportunity to finally visit and see a milk bank and speak to the person responsible to gain more practical insight into human milk banking in the UK, instead of only reading about it for my research.

human-donor-milk
Human donor milk comes from mothers who have had several blood tests and is collected from the mothers’ homes by the milk bank staff and/or the blood bikes. The frozen milk then gets processed in the milk bank, which means it is tested for microbiological contamination and pasteurised (heat treated) to make it save for the premature or sick babies to receive. This has been shown to increase their chance of survival and help their development.
Thank you Anita for taking all the time to answer my questions and for showing me around, as well as Bournemouth University for the funding which made my trip possible!

 

UKAMBIf you would like to find out more about human milk banking in the UK or want to become a human milk donor visit the UK Association for Milk Banking website at http://www.ukamb.org/.

 

If you would like to learn more about our research, please feel free to contact me at inessel@bournemouth.ac.uk

Isabell

BU PGR Research into the effects of diet and exercise on mobility and brain function – Call for participants.

PG research, student research

bike-pictureWe are often reminded that we should be paying attention to what we eat and making sure we exercise regularly. These recommendations are based on years of research into how diet and exercise can impact our health and well-being throughout the lifespan. However, it’s rare that these two crucial elements are studied together.

  • Can combining different lifestyle interventions produce an even more profound effect than each individually?
  • Are people able to adapt to two changes in lifestyle?
  • Is one element of lifestyle modification better than the other?

We have designed a study that will hopefully give an insight into these questions by looking at the effects of a dietary supplement and exercise classes on a spinning bike in adults aged 60+. The supplement contains fish oil (1000 mg DHA, 160 mg EPA), 20 µg B12, 1 mg folic acid, 124 mg phosphatidylserine, 240 mg gingko biloba standardized leaf extract and 20 mg vitamin E.

We are seeking to recruit healthy adults aged 60+ to take part in the study.  Volunteers will be split into four groups.

  • Supplement and exercise classes
  • Placebo and exercise classes
  • Supplement
  • Placebo

We will ask volunteers to take part in tests related to walking ability and brain function and a blood sample will also be required.  These will be done at the beginning of the study and after 24 weeks.

All testing and the exercise classes will take part at SportBU at Bournemouth University Talbot Campus, Fern Barrow, Poole, BH12 5BB.

  • Inclusion criteria: Aged 60+ and able to walk 50 metres without a walking aid
  • Exclusion criteria: Vestibular impairments (balance disorder), diagnosed neurological disorder e.g. dementia or depression, previously received lower limb surgery, diagnosis or receiving treatment for pernicious anaemia, allergy to seafood, regular consumption of multivitamin/fish oil supplements in the last six months, have been advised not to take part in exercise by a doctor

Due to a number of advances in medicine and healthcare, life expectancy has steadily increased in the UK meaning we have an ever expanding population of people aged 60+.  For this population it’s not just about living longer, it’s about living better for longer.  This can mean being able to take part in leisure activities like sports, gardening or visiting friends right down to more vital activities like being able to climb stairs or rise from a chair.  Mobility and brain function play a pivotal role in the quality of life of the older generation, yet it’s common to see declines in both of these areas as we get older.

I stumbled upon a website called Shoppok while browsing for a Honda 70 bike, and it offered a variety of listings. It’s always fascinating to discover new platforms where people can buy and sell items, including vehicles like motorcycles.

If you or anyone you know would be interested in taking part of would like more information about the study or our research please contact

Paul Fairbairn

PhD Student Bournemouth University

07871 319620

pfairbairn@bournemouth.ac.uk

chair-old-lady

BU’s PhD student Isabell Nessel attending the UK Association for Milk Banking annual training day in London, 8th of June

conferences, PG research

UKAMB Training Day2

The UK Association for Milk Banking (UKAMB) recently held their annual training day in London (Picture: Isabell and UKAMB’s Trustee Chair Ann McCrea). Mostly, milk bank staff were present; however, the training day is also open to anyone interested in human milk banking. Therefore, milk donors, medical researchers, midwives, neonatal nurses and clinicians were also in attendance. The presentations included current topics such as the Zika virus and the implications for milk banking, new guidance on decontamination of breast milk pumps and an update of ongoing research at donor milk banks.

As part of this, I presented my proposed donor milk bank survey, which is part of my PhD at BU. I received a great deal of helpful feedback and support from UKAMB and the audience. It was a great opportunity to get more insights into human milk banking and ongoing research in the UK and to network with potenital participants of the survey and possible future collaborators. Thanks to Bournemouth University for the funding, which made my attendance possible!

A big thank you also goes to Gillian Weaver and UKAMB for the invitation,UKAMB and this great, informative day! If you would like to find out more about human milk banking in the UK or want to become a milk donor visit UKAMB’s website at http://www.ukamb.org/.

If you would like to learn more about our research, please feel free to contact me at inessel@bournemouth.ac.uk

Isabell

Human Milk Banking in the UK

PG research, student research

UKAMBBreast feeding is the gold standard for feeding babies. This might not be surprising for most of you, although the rates of exclusive breast feeding in the UK are low. But have you ever heard of human milk banking? The UK Association for Milk Banking (UKAMB) does an incredible job in providing safe and screened donor breast milk all over the country through 16 donor milk banks, mostly to preterm babies whose mothers cannot provide sufficient breast milk. Feeding human donor milk instead of formula milk is for example associated with a lower risk for the severe gut infection necrotising enterocolitis.

Breast milk and donor milk also contain omega-3 and omega-6 polyunsaturated fatty acids, which are essential for brain and visual development in early infancy. However, research based at BU has identified that the current intake levels of preterm infants are too low to match the in utero accretion rates. Therefore, the aim of my PhD project at BU is to investigate approaches to increase the intake of omega-3 and omega-6 polyunsaturated fatty acids in preterm babies to improve their outcomes. One aspect I will be looking at is the intake from donor milk. Therefore, I was invited by the UK Association for Milk Banking to give a short presentation about my research at their annual training day in June.

I am looking forward to meeting donor milk bank staff and other researchers in the field of human milk banking at this day. I will post more details after the event. If you have any questions in the meantime, please feel free to contact me at inessel@bournemouth.ac.uk

If you would like to find out more about human milk banking in the UK or want to become a milk donor visit UKAMB’s website at http://www.ukamb.org/.

Isabell