MS is a chronic debilitating and progressive condition that affects the fatty tissue sheath surrounding nerves. Incomplete innervation due to loss of the myelin sheath is largely responsible for uncoordinated movements. Brain temperature fluctuations are also often seen in people with MS together with fatigue when carrying out mentally or physically demanding tasks. These are commonly associated with excessive yawning yet the cause of fatigue in MS is not well understood.
A recently completed study asked participants to produce saliva into a small tube so that their cortisol levels could be analysed. They were also asked to look at presentations that provoked a yawning response. Results revealed that all of the participants had elevated cortisol levels after yawning and that there was a marked difference in cortisol levels between the healthy participants and those with MS.

Yawning: Pynq Thompson aged 28 days
Thompson Cortisol Hypothesis (Ref.1) proposes threshold levels of cortisol trigger the yawn response which lowers brain temperature. Correlation between brain temperature and cortisol is to be further examined together with comparison between UK and Norwegian participants with MS since the incidence of MS is greater in Scandinavian countries (and Canada and Scotland) possibly due to vitamin D and K reduction with reduced sunlight.
Previous studies have examined electromyograph (EMG) activity during yawning and manipulation of conditions to provoke yawning (Refs. 2,3). Brain regions and cortisol activity has been identified in MS in an international study (Ref. 4); and a new understanding proposed of communication between the motor cortex and brain-stem (Ref.5).

Yawning EMG “envelope” of activity
A funding bid is being prepared to examine the feasibility of producing the early detection of MS and cortisol-insufficiency syndromes using observed yawning frequency and cortisol levels.
Simon B N Thompson is Associate Professor, Bournemouth University; Visiting Professor, Université Paris Ouest Nanterre La Défense, France. Member of International Scientific Council for Research into Multiple Sclerosis following presentation to French Ambassador, His Excellency Bernard Emié, French Embassy.
Acknowledgements
Thanks to all volunteers; Alister Coleman and Nicola Williams for assisting in data collection and analysis; Rod Slip, Group Co-ordinator and Kay Bundy, Fundraising Co-ordinator of the MS Society Osborne Centre for providing free facilities.
Note
The author would welcome interest in collaborating in writing bids for funding international work.
References
1. Thompson, S.B.N., 2011. Born to yawn? Cortisol linked to yawning: a new hypothesis. Medical Hypotheses, 77, 861-862.
2. Thompson, S.B.N., & Bishop, P., 2012. Born to yawn? Understanding yawning as a warning of the rise in cortisol levels: randomized trial. Interactive Journal of Medical Research, 1(2), e4, 1-9, doi: 10.2196/ijmr.2241.
3. Thompson, S.B.N., Frankham, C., & Bishop, P., 2014. The art of capturing a yawn using the science of nerve impulses and cortisol levels in a randomized controlled trial. Thompson Cortisol Hypothesis as a potential predictor of neurological impairment. International Journal of Arts & Sciences, 7(3), 529-543.
4. Thompson, S. B. N., Daly, S., Le Blanche, A., Adibi, M., Belkhiria, C., Driss, T., de Marco, G., 2016. fMRI randomized study of mental and motor task performance and cortisol levels to potentiate cortisol as a new diagnostic biomarker. Journal of Neurology & Neuroscience, 7(2); 92: 1-8.
5. Thompson, S.B.N., 2017. Hypothesis to explain yawning, cortisol rise, brain cooling and motor cortex involvement of involuntary arm movement in neurologically impaired patients. Journal of Neurology & Neuroscience, 8(1); 167: 1-5.
esearch, (led by me, Dr Paul Hartley), was recognised at UK Kidney Week in Liverpool last week. We were invited to speak about our fruit fly model of human renal disease, work that has been variously supported by grants from the British Heart Foundation and Kidney Research UK. The conference was an excellent opportunity to showcase the model and highlight our current collaborations with consultant-scientists based at Great Ormond Street Children’s Hospital as well as a number of different groups at the University of Bristol, the University of Osnabruck in Germany, Harvard Children’s Hospital and the University of Edinburgh. The research work is based in Dorset House labs and is supported by a wide network of talented people within BU as well as our undergrad and post-grad students.

Having just completed my Undergraduate degree in Psychology, I have embarked on a summer Research Assistant position working with the Ageing and Dementia Research Centre (ADRC) here at Bournemouth University. I will be working closely with an expert team within the research centre – Dr. Michele Board, Dr. Jane Murphy, Dr. Michelle Heward, and Ashley Spriggs, who hav
e all dedicated their careers to this particular field.





























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