Tagged / Systematic Review

CWLTH Research Seminar

The Centre for Wellbeing and Long-Term Health (CWLTH) will be hosting its first virtual Research Seminar of the new academic year on Thursday 27th October at 13:00.  Dr Heidi Singleton will be speaking about her systematic review of interventions for managing eczema.  All are welcome to attend by clicking HERE.  For more information about this meeting or for information about the CWLTH, please contact cwlth@bournemouth.ac.uk.

Congratulations to Heidi Singelton & Steve Ersser

In late August Heidi Singleton led the publication of a Cochrane Systematic Review under the title ‘Educational and psychological interventions for managing atopic dermatitis (eczema)’ [1].  The team conducting this review includes BU’s Prof. Steve Ersser, University Hospitals Dorset NHS Foundation Trust colleagues Dr. Andrew Hodder, former BU staff Prof. Vanessa Heaslip (currently at the University of Salford), and one of my co-authors on a previous project Dr. Dwayne Boyers from the Health Economics Research Unit at the University of Aberdeen.

In their review the authors conclude that in-person, individual education, as an adjunct to conventional topical therapy, may reduce short-term eczema signs compared to standard care, but there is no information on eczema symptoms, quality of life or long-term outcomes. Group education probably reduces eczema signs and symptoms in the long term and may also improve quality of life in the short term. Favourable effects were also reported for technology-mediated education, habit reversal treatment and arousal reduction therapy. All favourable effects are of uncertain clinical significance, since they may not exceed the minimal clinically important difference (MCID) for the outcome measures used.  Finally, they found no trials of self-help psychological interventions, psychological therapies or printed education. Future trials should include more diverse populations, address shared priorities, evaluate long-term outcomes and ensure patients are involved in trial design.

 

Well done!

Prof. Edwin van Teijlingen

CMWH

Reference:

  1. Singleton, H., Hodder, A., Almilaji, O., Ersser, S. J., Heaslip, V., O’Meara, S., Boyers, D., Roberts, A., Scott, H., Van Onselen, J., Doney, L., Boyle, R. J., & Thompson, A. R. (2024). Educational and psychological interventions for managing atopic dermatitis (eczema). The Cochrane database of systematic reviews8(8), CD014932. https://doi.org/10.1002/14651858.CD014932.pub2

New midwifery publication

Congratulations to Ph.D. student Joanne Rack on the publication today of her paper ‘Understanding perceptions and communication of risk in advanced maternal age: a scoping review (protocol) on women’s engagement with health care services’  [1].   Joanne doing a Clinical Doctorate in the Centre for Midwifery & Women’s Health (CMWH) focusing on personalised care for women of advanced maternal age.  Her doctoral study is matched-funded by University Hospitals Dorset NHS Foundation Trust and Bournemouth University [BU].  Her PhD is supervised and supported by Profs. Vanora Hundley, Ann Luce and Edwin van Teijlingen at BU and Dr. Latha Vinayakarao in Poole Maternity Hospital.

Well done!

 

Reference:

  1. Rack, J., Hundley, V., van Teijlingen, E., Luce, A., Vinayakarao. L. (2024) Understanding perceptions and communication of risk in advanced maternal age: a scoping review (protocol) on women’s engagement with health care services, MIDIRS Midwifery Digest, 34(3): 201-204.

BU e-health paper read 4,000 times

Our paper ‘Midwives’ views towards women using mHealth and eHealth to self-monitor their pregnancy: A systematic review of the literature’ [1] reached 4,000 reads on ResearchGate today.  Obviously, there is a growing interest in the use of mobile apps as well as the more general application of mHealth and eHealth in the UK and elsewhere.

 

Prof. Edwin van Teijlingen

Centre for Midwifery & Women’s Health

Reference:

  1. Vickery, M., van Teijlingen, E., Hundley, V., Smith, G. B., Way, S., Westwood, G. (2020). Midwives’ views towards women using mHealth and eHealth to self-monitor their pregnancy: A systematic review of the literature. European Journal of Midwifery4: 1-11. https://doi.org/10.18332/ejm/126625

Paper published on ‘living evidence’

The Nepal Journal of Epidemiology published today carries an article on so-called ‘living evidence’ as an on-going synthesis approach that provides up-to-date rigorous research evidence [1].  This short research methods paper argues that living evidence is particularly useful in rapidly expanding research domains, uncertain existing evidence, and incorporating new research evidence that may impact policy or practice, ensuring that health worker, managers and health-policy makers have access to the best, i.e. the most recent evidence.

The Nepal Journal of Epidemiology is an Open Access journal, and hence freely available to researchers across the globe.  The paper has been co-authored by researchers from the Denmark, Qatar, Mauritius and the UK.

 

Prof. Edwin van Teijlingen

Centre for Midwifery & Women’s Health (CMWH)

 

Reference:

  1. Sathian B., van Teijlingen E., do Nascimento I.J.B., Khatib M.N., Banerjee I., Simkhada P., Kabir R., Al Hamad H. (2023) Need for evidence synthesis for quality control of healthcare decision-making. Nepal Journal of Epidemiology 13(3):1288-1291.  DOI: 10.3126/nje.v13i3.61004

Advertising BU’s Systematic Review Masterclass

The Faculty of Health & Social Sciences shall be running the two-day ONLINE MasterclassIntroduction to conducting a systematic literature review’.  The aim is to provide participants with an understanding of how to collate and assess the best possible evidence in the form of a systematic literature review. This masterclass will examine the rationale for systematic literature reviews and take participants through the structured, rigorous, and objective approach used to provide a critical synthesis of the available evidence on a particular topic.

The Masterclass is facilitated by (1) Vanora Hundley, Professor in Midwifery with experience of conducting systematic reviews of health care interventions in both low-and-high-income countries; (2) Edwin van Teijlingen, a medical sociologist with extensive experience in conducting systematic reviews. He has run similar workshops reviews internationally and has published on the importance of systematic reviews; and (3) Caspian Dugdale is Research Librarian with considerable experience in running health information literacy workshops for students, academics and postgraduate researchers.

The masterclass is suitable for anyone who wishes to explore the basic principles involved in conducting a systematic literature review. No previous knowledge is required. Attendees include health and social care practitioners, postgraduate students, and academics.  There will be two online days – 8th and 15th November – which will focus on:

  • Designing a review protocol
  • Formulating a question
  • Identifying and selecting relevant studies
  • Systematic data extraction and collection
  • Synthesis and analysis of the data
  • Writing up and reporting systematic reviews.

Booking Information:

The fee of £400 includes two full days with the course facilitators. We are happy to announce that NHS partner organisations are eligible for a reduced fee £200.

You are now able to book on line for our masterclass: https://www.applycpd.com/BU/courses/116678

The application deadline is 11th October 2023.

For more information contact:
Tel: 01202  962184 or email HSSRKEAdministrator@bournemouth.ac.uk

Last BU paper of 2021

The scientific journal Nepal Journal of Epidemiology published its fourth and final issue of 2021 on December 31.  This issue included our systematic review ‘Epidemiologic characteristics, clinical management and Public Health Implications of Coronavirus Disease 2019 (COVID-19) in Pregnancy: A Systematic Review and meta-analysis’.  This review covered the published literature on the epidemiology, clinical management and public health prevention aspects of pregnancy and childbirth and coronavirus (COVID-19) up until December 2020.  We worked hard and fast to submit the paper as soon as possible after the end of 2020 to be able to publish up-to-date findings.  We managed this and submitted the paper on March 5th, the peer-review took some months and so did the making of the revisions.  As a result we resubmitted the manuscript of 29 September and we got the acceptance email within a week.  We made it into the next issue of the Nepal Journal of Epidemiology which published exactly one year after the data collection period had ended for our systematic review.

There are two lessons here, first even when submitting to an online journal one will experience a delay in publishing.  Secondly, the 36 papers we had appraised and included were published in 2020, meaning these scientific  papers were submitted in mid-2020 at the latest in order to make it through the peer-review process, get accepted and formatted for online publication.

In the resubmitted version we had to add as a weakness of this review that: “It is worth noting that this extensive systematic review only cover papers published in 2020, and hence studies conducted in or before 2020. This was before the emergence of variants of COVID-19, especially the delta and omicron variants.”

 

Prof. Edwin van Teijlingen

CMMPH (Centre for Midwifery, Maternal & Perinatal Health).

New BU reproductive health paper

Congratulations to Dr. Pramod Regmi (Lecturer in International Health) in the Department of Nursing Sciences on today’s publication of ‘The unmet needs for modern family planning methods among postpartum women in Sub-Saharan Africa: a systematic review of the literature’ [1].  The paper in the international peer-reviewed journal Reproductive Health is co-produced with BU MSc Public Health graduate Jumaine Gahungu and Dr. Mariam Vahdaninia who left the Faculty of Health & Social Sciences in mid-2020. 

Well done.

Prof. Edwin van Teijlingen

CMMPH

 

Reference:

  1. Gahungu, J., Vahdaninia, M. & Regmi, P. (2021) The unmet needs for modern family planning methods among postpartum women in Sub-Saharan Africa: a systematic review of the literature. Reprod Health 18, 35   https://doi.org/10.1186/s12978-021-01089-9

Congratulations on academic paper by BU PhD student Orlanda Harvey

Congratulations to Orlanda Harvey, PhD student in the Faculty of Health & Social Sciences on her PhD publication “Support for people who use Anabolic Androgenic Steroids: A Systematic Scoping Review into what they want and what they access” in the Open Access journal BMC Public Health [1].  Since there is a paucity of research on support for people using Anabolic Androgenic Steroids (AAS), this article searched and synthesised the available evidence in this field. Gaining an understanding of the support both accessed and wanted by recreational AAS users will be of use to professionals who provide services to intravenous substance users and also to those working in the fields of public health and social care, with the aim to increase engagement of those using AAS.

This systematic scoping review identified 23 papers and one report for review, which indicated that AAS users access a range of sources of information on: how to inject, substance effectiveness, dosages and side effects, suggesting this is the type of information users want. AAS users sought support from a range of sources including medical professionals, needle and syringe programmes, friends, dealers, and via the internet, suggesting that, different sources were used dependent on the information or support sought.

The authors argue that AAS users tended to prefer peer advice and support over that of professionals , and access information online/specialist fora, reflecting the stigma that is experienced by AAS  users. These tendencies can act as barriers to accessing services provided by professionals.  The paper concludes that support needs to be specific and targeted towards AAS users. Sensitivity to their perceptions of their drug-use and the associated stigma of being classified in the same sub-set as other illicit drug users is relevant to facilitating successful engagement.

 

Reference: 

  1. Harvey, O., Keen, S., Parrish, M., van Teijlingen, E. (2019) Support for people who use Anabolic Androgenic Steroids: A Systematic Literature Review into what they want and what they access. BMS Public Health 19: 1024      https://rdcu.be/bMFon

 

 

BU Systematic Review Masterclass starting tomorrow

Looking forward to our annual Systematic Review Masterclass at Bournemouth University which will be starting tomorrow February 14th.  This year for the first time we have renamed it a ‘Systematic Review to Inform Clinical Practice’ as it is not only a free-standing masterclass but also a level 7 unit of Continuing Professional Development and Training .  This year we aim to provide students with the opportunity to choose an area of interest and undertake an in-depth, independent study in the form of a systematic review, focusing on a negotiated aspect of clinical practice.  Prof. Vanora Hundley and I had published over twenty systematic reviews (or papers about systematic reviewing) over the past two decades. [1-21]  The unit will have input from BU’s Academic Liaison Librarian, Caspian Dugdale, and BU academics such as Dr. Bibha Simkhada, Lecturer in Nursing.

Professors Vanora Hundley and Edwin van Teijlingen

Centre for Midwifery, Maternal & Perinatal Health (CMMPH)

 

References:

  1. van Teijlingen E, Wilson, B, Barry, N, Ralph, A, McNeill, G, Graham, W, Campbell, D. (eds.) (1998) Effectiveness of interventions to promote healthy eating in pregnant women & women of childbearing age: a review, London: Health Education Authority www.nice.org.uk/nicemedia/documents/effect_eatpregant.pdf  [ISBN: 0752110977].
  2. van Teijlingen ER, Bruce, J. (1999) Systematic reviews of health promotion initiatives: the Smokebusters experience, Health Education, 99: 76-83.
  3. Ryan M, Scott DA, Reeves C, Bate A., van Teijlingen E, Russell E, Napper M, Robb C (2001) Eliciting public preferences for healthcare: systematic review of techniques. Health Technology Assessment 5(5)
  4. Simkhada, B., van Teijlingen E., Porter, M., Simkhada, P. (2008) Factors affecting the utilisation of antenatal care in developing countries: a systematic review of the literature, Journal of Advanced Nursing 61(3): 244-260.
  5. Paul-Ebhohimhen, V.A., Poobalan, A., van Teijlingen E. (2008) Systematic review of effectiveness of school-based sexual health interventions in Sub-Saharan Africa, BMC Public Health, 8(4). www.biomedcentral.com/1471-2458/8/4
  6. Robertson L, Douglas F, Ludbrook A., Reid G., van Teijlingen E. (2008) What works with men? A systematic review of health promoting interventions targeting men, BMC Health Services Research 8(141). www.biomedcentral.com/1472-6963/8/141
  7. Acharya, D.R., Bhattarai, R, Poobalan, A, van Teijlingen E.R., Chapman, G. (2010) Factors associated with teenage pregnancy in South Asia: a systematic review. Health Sciences Journal 4(1): 3-14. www.hsj.gr/volume4/issue1/402.pdf
  8. Hundley V, Avan B, Braunholtz D, and Graham WJ (2012). Are birth kits a good idea? A systematic review of the evidence. Midwifery 28(2): 204-215
  9. Wasti, SP, van Teijlingen E., Simkhada, P., Randall, J., Baxter S, Kirkpatrick P, Vijay Singh Gc. (2012) Factors influencing adherence to antiretroviral treatment in Asian developing countries: a systematic review, Tropical Medicine & International Health 17(1): 71-81. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3156.2011.02888.x/pdf
  10. VA Hundley, BI Avan, CJ Sullivan, WJ Graham. (2013) Should oral misoprostol be used to prevent postpartum haemorrhage in home-birth settings in low-resource countries? A systematic review of the evidence. BJOG: An International Journal of Obstetrics & Gynaecology120:277287DOI: 10.1111/1471-0528.12049
  11. van Teijlingen, ER, Simkhada, B., Ireland J., Simkhada P., Bruce J. (2012) Evidence-based health care in Nepal: The importance of systematic reviews, Nepal Journal of Epidemiology 1(4): 114-118.
  12. Robertson, C, Archibald, D, Avenell, A, Douglas, F., Hoddinott, P., van Teijlingen E, et al. (2014) Systematic reviews of & integrated report on quantitative, qualitative & economic evidence base for the management of obesity in men. Health Technology Assessment 18(35): 1-424. http://www.journalslibrary.nihr.ac.uk/__data/assets/pdf_file/0019/118180/FullReport-hta18350.pdf
  13. Stewart, F, Fraser, C, Robertson, C, Avenell, A, Archibald, D, Douglas, F, Hoddinott, P, van Teijlingen, E, Boyers, D. (2014) Are men difficult to find? Identifying male-specific studies in MEDLINE & Embase, Systematics Reviews 3,78
  14. Gyawali, B., Neupane, D., Sharma, R., Mishra, S.R., van Teijlingen, E., Kallestrup, P. (2015) Prevalence of type 2 diabetes in Nepal: Systematic review & meta-analysis from 2000 to 2014 Global Health Action 8: 29088 www.globalhealthaction.net/index.php/gha/article/view/29088/pdf_189
  15. Boyers, D, Stewart, F, Fraser, C, Robertson, C, Avenell, A, Archibald, D, Douglas, F, Hoddinott P, van Teijlingen E. (2015). A systematic review of the cost-effectiveness of non-surgical obesity interventions in men, Obesity Research & Clinical Practice 9(4), 310-327.
  16. Robertson, C, Avenell, A, Boachie, C., Stewart, F., Archibald D., Hoddinott, P, Douglas, F, van Teijlingen E, Boyers D. (2016) Should weight loss and maintenance programmes be designed differently for men? Systematic review of long-term RCTs presenting data for men & women: The ROMEO Project, Obesity Research & Clinical Practice 10: 70-84.
  17. Simkhada, P.P., Sharma, A., van Teijlingen, ER., Beanland, R,L. (2016) Factors influencing sexual behaviour between tourists and tourism employees: A systematic review. Nepal Journal of Epidemiology 6(1): 530-538. www.nepjol.info/index.php/NJE/article/view/14735/11952
  18. Symon, A., Pringle, J., Cheyne, H., Downe, S., Hundley, V., Lee, E., Lynn, F., McFadden, A., McNeill, J., Renfrew, M., Ross-Davie, M., van Teijlingen, E., Whitford, H, Alderdice, F. (2016) Midwifery-led antenatal care models: Mapping a systematic review to an evidence-based quality framework to identify key components & characteristics of care, BMC Pregnancy & Childbirth 16: 168 http://rdcu.be/uifu  
  19. Hanley GE, Munro S, Greyson D, Gross MM, Hundley V, Spiby H and Janssen PA (2016) Diagnosing onset of labor: A systematic review of definitions in the research literature. BMC Pregnancy and Childbirth 16: 71 http://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-016-0857-4
  20. Robertson, C., Avenell, A., Stewart, F., Archibald, D., Douglas, F., Hoddinott, P., van Teijlingen, E., Boyers, D. (2017) Clinical effectiveness of weight loss & weight maintenance interventions for men: a systematic review of men-only randomised controlled trials (ROMEO Project), American Journal of Men’s Health 11(4): 1096-1123.
  21. Symon, A., Pringle, J., Downe, S., Hundley, V., Lee, E., Lynn, F., McFadden, A., McNeill, J., Renfrew, M., Ross-Davie, M., van Teijlingen, E., Whitford, H., Alderdice, F. (2017) Antenatal care trial interventions: a systematic scoping review and taxonomy development of care models BMC Pregnancy & Childbirth 17:8 http://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-016-1186-3
  22. Pitchforth, E, Nolte, E, Corbett, J, Miani, C, Winpenny, E, van Teijlingen E, et al. (2017) Community hospitals and their services in the NHS: identifying transferable learning from international developments – scoping review, systematic review, country reports and case studies Health Services & Delivery Research 5(19): 1-248.
  23. Ochillo, M., van Teijlingen, E., Hind, M. (2017) Influence of faith-based organisations on HIV prevention strategies in Africa: a systematic review. African Health Sciences 17(3): 753-761.
  24. Mahato, P., van Teijlingen, E., Simkhada, P., Angell, C. (2017) Determinants of quality of care & access to Basic Emergency Obstetric & Neonatal Care facilities & midwife-led facilities in low & middle-income countries: A Systematic Review, Journal of Asian Midwives 4(2):25-51. https://ecommons.aku.edu/jam/vol4/iss2/4/
  25. Simkhada, P., van Teijlingen, E., Sharma, A., Bissell, P., Poobalan, A., Wasti, S.P. (2018) Health consequences of sex trafficking: A systematic review, Journal of Manmohan Memorial Institute of Health Sciences, 4(1): 130-149.

 

“New” FHSS paper on obesity published July 2017


The American Journal of Men’s Health published our latest paper on obesity prevention in men.  The paper ‘Clinical Effectiveness of Weight Loss and Weight Maintenance Interventions for Men: A Systematic Review of Men-Only Randomized Controlled Trials (The ROMEO Project)’ originates from a collaboration between BU and various universities in Scotland, led by the University of Aberdeen [1].

This systematic review paper found that reducing diets produced better weight loss than physical activity alone. The most effective interventions combined reducing diets, exercise, and behaviour change techniques . Group interventions produced favourable weight loss results. The paper reports that once engaged, men remained committed to a weight loss intervention.

The paper concludes that weight loss for men is best achieved and maintained with the combination of a reducing diet, increased physical activity, and behaviour change techniques. Strategies to increase engagement of men with weight loss services to improve the reach of interventions are needed.  This paper is the thirteenth paper from a large NIHR grant [2-13].

The American Journal of Men’s Health is an open access, peer-reviewed resource for cutting-edge information regarding men’s health and illness. It is, however worth noting that although our paper is formally published in July 2017 it has been online for two years!  The journal’s website states clearly that the article was first published online on June 30, 2015 BUT the issue in which it appears is published is July 1, 2017!

 

Prof. Edwin van Teijlingen

CMMPH

 

Reference:

  1. Robertson, C., Avenell, A., Stewart, F., Archibald, D., Douglas, F., Hoddinott, P., van Teijlingen, E., Boyers, D. (2017) Clinical effectiveness of weight loss & weight maintenance interventions for men: a systematic review of men-only randomised controlled trials (ROMEO Project), American Journal of Men’s Health 11(4): 1096-1123.  http://journals.sagepub.com/doi/full/10.1177/1557988315587550
  2. Robertson, C, Archibald, D, Avenell, A, Douglas, F., Hoddinott, P., van Teijlingen E, Boyers, D., Stewart, F, Boachie, C, Fioratou E., Wilkins, D, Street, T., Carroll, P., Fowler, C. (2014) Systematic reviews of & integrated report on quantitative, qualitative & economic evidence base for the management of obesity in men. Health Technology Assessment 18(35): 1-424. http://www.journalslibrary.nihr.ac.uk/__data/assets/pdf_file/0019/118180/FullReport-hta18350.pdf
  3. Stewart, F., Fraser, C., Robertson, C., Avenell, A., Archibald, D., Douglas, F., Hoddinott, P., van Teijlingen, E., Boyers, D. (2014) Are men difficult to find? Identifying male-specific studies in MEDLINE and Embase, Systematics Reviews 3,78.
  4. Archibald, D, Douglas, F, Hoddinott, P, van Teijlingen, E, Stewart, F., Robertson, C., Boyers, D., Avenell, A. (2015) A qualitative evidence synthesis on management of male obesity. BMJ Open 5: e008372. doi:10.1136/bmjopen-2015-008372 http://bmjopen.bmj.com/content/5/10/e008372.full.pdf+html
  5. Boyers, D, Stewart, F, Fraser, C, Robertson, C, Avenell, A, Archibald, D, Douglas, F, Hoddinott P, van Teijlingen E. (2015). A systematic review of the cost-effectiveness of non-surgical obesity interventions in men, Obesity Research & Clinical Practice 9(4), 310-327.
  6. Robertson, C, Avenell, A, Boachie, C., Stewart, F., Archibald D., Hoddinott, P, Douglas, F, van Teijlingen E, Boyers D. (2016) Should weight loss and maintenance programmes be designed differently for men? Systematic review of long-term RCTs presenting data for men & women: The ROMEO Project, Obesity Research & Clinical Practice 10: 70-84.
  7. Robertson, C., Avenell, A., Boachie, C., Stewart, F., Archibald, D., Douglas, F., Hoddinott, P., van Teijlingen, E., Boyers, D. (2015) Should weight loss programmes be designed differently for men and women? The ROMEO Project, Appetite 87: 374.
  8. Robertson, C., Avenell, A., Stewart, F., Archibald, D., Douglas, F., Hoddinott, P., van Teijlingen, E., Boyers, D. (2015) A systematic review of long-term weight management randomized controlled trials for obese men. The ROMEO Project, Appetite 87: 374.
  9. Robertson, C., Avenell, A., Stewart, F., Archibald, D., Douglas, F., Hoddinott, P., van Teijlingen, E., Boyers, D. (2015) A systematic review of weight loss interventions in the UK. The ROMEO Project, Appetite 87: 375.
  10. Boyers, D., Avenell, A., Stewart, F., Robertson, C., Archibald, D., Douglas, F., Hoddinott, P., van Teijlingen, E., (2015) A systematic review of the cost-effectiveness of non-surgical obesity interventions in men, Appetite 87: 375.
  11. Archibald, D., Douglas, F., Hoddinott, P., van Teijlingen, E., Boyers, D., Avenell, A., Stewart, F., Robertson, C., (2015) A qualitative evidence synthesis on the management of male obesity. The ROMEO Project, Appetite 87: 381.
  12. Avenell, A., Robertson, C., Boachie, C., Stewart, F Archibald, D., Douglas, F., Hoddinott, P., van Teijlingen, E. (2016) Sex based subgroup differences in randomized controlled trials: empirical evidence from Cochrane meta-analyses BMJ 355:i5826 http://www.bmj.com/content/355/bmj.i5826/rapid-responses
  13. Avenell, A., Robertson, C., Stewart, F., Boyers, D., Douglas, F., Archibald, D., van Teijlingen, E., Hoddinott, P., Boachie, C. (2016) Sex can affect participation, engagement, and adherence in trials, BMJ 355:i6754 http://www.bmj.com/content/bmj/355/bmj.i6754.full.pdf