Category / Post-award

Intranasal inhalation of oxytocin improves eye-witness identification: RDF grant report

BU research, Featured academics, Post-award, Research news

In 2011 myself and Ben Parris from the Psychology Research Centre were awarded a small RDF grant to investigate whether intranasal inhalation of the hormone oxytocin can improve eye-witness identification.  We designed an experiment where participants viewed a short video-clip of a perpetrator stealing a wallet from someone’s bag.  Participants then inhaled either an oxytocin or placebo nasal spray, and after a 45 minute interval to allow central oxytocin levels to plateau, were presented with a line-up of ten faces from which they had to either select the perpetrator or state that he was absent.  To date we have tested 70 participants and found a facilitation in the oxytocin condition.  In a second experiment, we asked participants to complete the ‘One-in-Ten’ task, a test of spontaneous eye-witness memory that has been well-used in previous work.  Again, we found a clear facilitation in performance in the oxytocin condition.

These findings follow recent work that has demonstrated that oxytocin can improve face recognition performance in standard cognitive tasks in lab-based settings.  In addition, work from our lab is currently under review for publication demonstrating that oxytocin can improve face recognition in individuals with prosopagnosia (face blindness).  This RDF grant has therefore given us the funding to carry out key investigations demonstrating novel applications of oxytocin inhalation in more applied settings.

I also presented findings from the oxytocin project at the April meeting of the Experimental Psychological Society, and was delighted to meet Dr Markus Bindemann from the University of Kent who is something of an expert in eye-witness identification.  We are now collaborating with Markus, and have plans to develop a bid to the Leverhulme Trust on the back of the publications that we hope will result from these investigations.  We are also about to welcome a new PhD student to our lab, who will be further developing the forensic aspect of this work in more real-world national security settings.

The pump-priming that was made available to us via the RDF scheme has provided us with the opportunity to collect the initial data and publication basis that we need to develop a large external bid, and we hope that this is the beginning of a fruitful line of research for our laboratory.

BUCRU – Seminar presenting Breaking News!

BU research, Post-award, Publishing, Research news, Uncategorized

 

BREAKING  NEWS…

We would like to invite you to an afternoon seminar by one of our Visiting Faculty, Professor Mike Wee, presenting some exciting new research findings to come out of a recently completed Research for Patient Benefit funded study comparing two methods of pain relief during labour (abstract and biography below).  This paper was just voted best paper of the conference at the Obstetric Anaesthetists Association Annual Conference in Liverpool and was featured recently in the Bournemouth Echo http://www.bournemouthecho.co.uk/news/9770928.Pain_relief_in_labour__study_at_Poole_hospital_makes_important_discovery/

The seminar is scheduled for Thursday 19th July 2-3pm in BG10 Bournemouth House (after the HSC end of term lunch and next door for your convenience).

We hope you can make it and look forward to seeing you then.

BUCRU

Website: http://microsites.bournemouth.ac.uk/bucru/

Administrator: +44 (0)1202 961939 / wardl@bournemouth.ac.uk

Title: The IDvIP Trial: A two-centre double blind randomised controlled trial comparing i.m. diamorphine and i.m. pethidine for labour analgesia

Research team and affiliations: MYK Wee, JP Tuckey,* P Thomas,† S Burnard,* D Jackson.

Poole Hospital NHS Foundation Trust, Poole, UK, *Royal United Hospital, Bath, UK, †Bournemouth University Clinical Research Unit, Bournemouth, UK.

Abstract:

Background: Intramuscular pethidine, the commonest parenteral opioid analgesic used in obstetrics and more recently diamorphine usage has increased in the UK.  The maternal, fetal and neonatal side effects are well known for pethidine but there are no sufficiently powered large RCTs comparing pethidine with diamorphine. The aim of this trial is to address this.

Methods: After ethical approval, informed consent was obtained from 484 women randomised to receive either 7.5mg diamorphine i.m. or 150mg pethidine i.m. for labour analgesia. The sample size calculation derived from a small RCT giving 90% power (at the 5% significance level) is based upon the maternal primary outcome measure of pain relief at 60mins and the neonatal primary outcome measures of Apgar Score of <7 at 1min and neonatal resuscitation. Secondary outcome measures include verbal pain intensity at 60mins and over 3hrs post-analgesia, pain relief over first 3hrs, maternal oxygen saturation, sedation, nausea and vomiting and maternal satisfaction with analgesia. Fetal and neonatal secondary outcomes include CTG trace, meconium staining, UApH, UVpH, time of delivery to first breath, Apgar Score at 5mins, naloxone use, neonatal oxygen saturations, sedation and feeding behaviour for the first 2hrs after delivery.

Results: Reported using CONSORT guidelines. At 60mins post-administration and over a 3hr period, diamorphine is better at reducing pain scores than pethidine (p<0.001). There were no statistical differences between the two groups regarding Apgar Scores of <7 at 1min and the need for neonatal resuscitation.  The time between first dose administered and delivery is on average 82mins longer with the diamorphine group compared to pethidine (p<0.001). The vast majority of women experienced moderate to severe pain at all times. Women receiving diamorphine were more satisfied with their analgesia. There were no statistically significant differences in maternal sedation, nausea and vomiting or oxygen saturations over the 3hr period. There were no statistically significant differences in the fetal and neonatal outcomes including feeding behaviour between the two groups within 2hrs of birth but neonates in the pethidine group were more likely to be moderately or severely sedated at delivery.

Discussion: Intramuscular 7.5mg diamorphine gives significantly better analgesia than 150mg pethidine but prolongs delivery by approx. 82mins.  Women given diamorphine are more likely to be satisfied with their analgesia.  The mechanism for the prolongation of delivery time in the diamorphine group should be investigated further.

Acknowledgement: This research was funded by the NIHR Research for Patient Benefit Programme (PB-PG-0407-13170).

References

1. Tuckey JP, Prout RE, Wee MYK. Prescribing intramuscular opioids for labour analgesia in consultant-led maternity units: a survey of UK practice. International Journal of Obstetric Anesthesia 2008, 17(1):3-8.

2. Fairlie FM, Marshall L, Walker JJ et al. Intramuscular opioids for maternal pain relief for labour: a randomised controlled trial comparing pethidine with diamorphine. British  Journal of Obstetrics and Gynaecology 1999; 106(11): 1181 -1187.

Biography of speaker:

Michael Wee is a consultant anaesthetist from Poole Hospital and Royal Bournemouth Hospitals.  He has a special interest in obstetric anaesthesia and is the lead obstetric anaesthetist at Poole Hospital.  He is chair of the Research and Innovations Group at Poole Hospital and is a Board member of the Western Comprehensive Local Research Network.  He was awarded a visiting professorship at Bournemouth University in 2009.  He is a referee for several medical journals.  His research interests include patient information, safety in anaesthesia, maternal analgesia and simulation in epidural anaesthesia.  He is a co-supervisor of a PhD student at BU and chief investigator of the MObs study investigating early warning scores in obstetrics.

An Introduction to Research Administration & Management

Awarded & submitted bids, BU research, Guidance, Post-award, R & KE Operations, Training

The Research & Knowledge Exchange Operations (RKE Ops) team will be hosting a lunchtime staff development session on ‘An Introduction to Research Administration and Management’ geared towards professional and support staff on the 11th July 2012 at 12.30pm.

The session will explore the basics around research administration and management, including an overview of full Economic Costing (fEC), the prominent research funders and general good practice in research project management.

Further details can be found below:

  • What? Introduction to Research Administration & Management
  • When? Wednesday 11th July, 12.30 to 13.30pm
  • Where? The Octagon, Library, Talbot Campus
  • Who? Professional and support staff interested in research administration.
  • How?  To book a place please click here

The R & KE Operations Team Are Moving!

BU research, Guidance, Post-award, R & KE Operations

 Space at Talbot Campus is scarce, so to make room for more student focused activities the R & KE Operations Team will be moving to Melbury House at the end of July.

We are confirming availability of hotdesks in each school to ensure members of the team will continue to be as accessible to Talbot Campus colleagues as possible, we are also incorporating hotdesks in our office in Melbury House which colleagues will be welcome to use.

The move itself will take place between Thursday 26th and Monday 30th July. Access to the team will be limited during this time, so please bear this in mind if you have any pending application deadlines or project needs and make provisions for support in advance where possible.

Many thanks,

The R & KE Operations Team

 

 

 

The EU Pod is launched!

BU research, EU, Guidance, Post-award

In response to feedback from across schools, the R & KE Operations team has been restructured to include a dedicated EU Pod headed up by Paul Lynch.

The pod will assume the post-award management of all current EU projects together with the pre-award management of  future EU applications across all schools and professional services.

 

So, if you’re interested in EU funding but don’t know how to get started with your application contact a member of the EU Pod:

Paul Lynch – Senior R & KE Officer (EU)

Alexandra Peirce – R & KE Officer (EU)

 

 

Ethics and Conduct and Governance….OH MY!!

Guidance, Post-award

Similar to Lions and Tigers and Bears, these nasty words often send a chill down the spine of researchers across the globe!

“More roadblocks to delay my research?!” 

“Hinder-full, not helpful!” 

“Once you think you’ve ticked all the boxes, read all the policy/procedure and signed your life away, SMACK – the conduct officer hits you with a new hurdle!”

Sound familiar?  These are just a few examples of the misconception towards my full-time job.  Hello, my name is Julia Hastings Taylor and I am the University’s Research Development Officer responsible for ethics and conduct.  Prior to joining BU I received my Masters in International Political Economy from LSE and before moving across the pond, I worked for the US Intelligence Community tracking down drug lords in SW Asia, Europe, and Africa.  Drug traffickers—as opposed to university researchers—tend to not concern themselves with ethics or conduct, so I’m pleased to be part of an organization that takes compliance seriously!

My first mission—as impossible as it may seem—is to change the way researchers view ethics and conduct (and me, for that matter).  I’m not the Big Bad Wolf and I don’t plan to ‘blow your research down’; on the contrary, I am here to support you, and strengthen the University’s research governance structure.  Leave the scary ethics maze to me – I know the way and I will point you in the right direction.  Struggling to understand and/or comply with funder regulations – don’t fret, it’s my job to ensure all regulations are clear and we have an easy-to-follow framework for compliance!  I plan to streamline processes and procedures, outline ‘best practices’ in both ethics and conduct and ensure that the University’s policies are not only robust but also flexible. 

While we’re on the topic, here are a few of my thoughts: while I wouldn’t consider myself to be a ‘tree hugger,’ I am sensible…so come on folks…this is 2012…let’s move away from printing off reams and reams of forms to fill in and sign when we can simply create online forms with digital signatures.  I like processes to be efficient, straightforward and simple and that’s what I hope to bring to the University’s ethics and conduct role.  As the next handful of months will bring change—and we all know how much everyone loves change—please give me your feedback and suggestions for improvements, and be honest about your views on research ethics and conduct; I’d like for this process to be as inclusive as possible, but I can only knock on so many doors, invite you to so many meetings/forums and ask so many questions.

So, if you happen to see me lurking around your School in the coming months, please don’t assume I’m the secret police looking for my next victim….I’m probably lost and simply trying to find the loo!

BUCRU – Supporting the development of grant applications

Awarded & submitted bids, BU research, Funding opportunities, Post-award, Publishing, Research assessment, Research news

In today’s post we give a case study of how Bournemouth University Clinical Research Unit (BUCRU) recently supported the development of a grant application.

Case study

We recently supported a Programme Development Grant (www.ccf.nihr.ac.uk/PGfAR/PDG/Pages/default.aspx) application to the National Health Service (NHS) National Institute for Health Research (NIHR). The Unit receives funding from the NIHR to be the Dorset Office of the NIHR Research Design Service (RDS), and thus can support local researchers in the University and the NHS to develop their funding applications. The topic of this grant application was early warning systems for use in an obstetric setting. Early warning systems are used by clinical staff in hospital to identify clinical problems before they get too serious, for example by regularly monitoring vital signs such as blood pressure. The purpose of Programme Development Grants is to fund preliminary work ahead of a larger Programme Grant for Applied Research (PGAR; www.ccf.nihr.ac.uk/PGfAR/Pages/Home.aspx). 

This support involved:

  • Providing methodological input in systematic reviews, surveys, qualitative designs, quantitative designs notably a sample size calculation, and trial design.
  • Patient and public involvement (PPI) – the team has a designated person supporting PPI.
  • Team development – a strong team needed to be developed with the appropriate skill mix to deliver the programme of research.  Four members of BUCRU became co-applicants on the proposal bringing methodological expertise in systematic reviews, qualitative research, quantitative research, and PPI support.  Via our link with the RDS we also have access to health economist support.   Collaborations were initiated with the Wessex Health Innovation and Education Cluster (HIEC; www.wessexhiecpartnership.org.uk/) to gain support in the educational/ training aspects of the research.  
  • Liaison – we liaised with a number of different organisations, such as Research and Knowledge Exchange Operations for costing the Bournemouth University (BU) costs, the NHS host organisation that will be responsible for the research, and the Market Research Group (MRG; https://mrg.bournemouth.ac.uk/) who were involved to support the administration and data entry for the survey component of the project.
  • Identification of appropriate funding schemes.
  • Obtained peer review from RDS colleagues across the region to provide feedback on the suitability of the funding scheme and the ‘readiness’ for submission. This service is usually provided through regular Scientific Committee meetings that act as ‘mock’ funding committees (www.rds-sw.nihr.ac.uk/scientific_committee.htm).

Quote from lead applicant: “Without the expertise and assistance of BUCRU staff it would not have been possible to even contemplate applying for a large and competitive grant such as the NIHR Programme Development Grant” .

Please contact us for support with health research:

Louise Ward (administrator):

Bournemouth University Clinical Research Unit

R505 Royal London House

Christchurch Road

Bournemouth BH1 3LT

BUCRU@bournemouth.ac.uk

Tel: 01202 961939

http://blogs.bournemouth.ac.uk/bucru/

People at Bournemouth University Clinical Research Unit (BUCRU)

Awarded & submitted bids, BU research, Post-award, Publishing, Research assessment, Research news

In yesterday’s posting we gave a brief introduction to BUCRU. Today we introduce you to the members of the team.

 

Louise Ward

Louise is one of the administrators for the unit and has been with the team since 2008.  She has worked in various NHS settings and has an interest in marketing.  Both her undergraduate and Masters degrees were studied here at Bournemouth University.

Professor Paul Thompson

Paul is Consultant Rheumatologist at Poole Hospitaland Visiting Professor at BU. He was appointed Director of the Centre of Postgraduate Medical Research and Education (CoPMRE) in 2007, where he has been leading developments between research and education active doctors in NHS Trusts and the academic community at the University. He is Co-director of BUCRU, Lead for the musculoskeletal local priority group for the Western Comprehensive Local Research Network (CLRN) and Fellow of the NHS Improvement Faculty. He is interested in clinical research and service development in the rheumatic diseases. He supervises PhD students and is an External Examiner at other Universities.

Dr Sarah Thomas

Sarah is Deputy Director (methodology). She has a background in psychology and since 2000 has worked in the NHS in Dorset.  As well as supporting other researchers in a Research Design Service capacity, she also conducts research. Her main research interests are in the field of multiple sclerosis (MS) and she is currently Chief Investigator for a pilot study funded by the UK MS Society exploring the use of the Nintendo Wii™ in people with MS.

Professor Peter Thomas

Peter is Co-Director and leads on research methodology. He has a background in epidemiology and statistics, and has been with Bournemouth University since 1996. He has a special research interest in psychosocial aspects of chronic disease and much of his recent work has focussed on multiple sclerosis.

Dr Zoe Sheppard

Zoe is a demographer with particular experience investigating socio-economic status.  She joined Bournemouth University in October 2009 as a Research Fellow in Research Methods.  She provides research methods support for people doing health research and support writing grant applications in her National Institute for Health Research (NIHR) Research Design Service (RDS) capacity.

Suzanne Sheppard

Suzanne is a Clinical Researcher recently recruited from the pharmaceutical industry to help manage the unit’s clinical trials.  She has experience in setting-up and monitoring clinical trials across phases 1 to 3 in a variety of therapeutic areas. 

Annabel Kenny

Annabel is a Clinical Research Administrator who joined Bournemouth University in October 2009.  She provides support to Dr. Tamas Hickish, Consultant Medical Oncologist, Royal Bournemouth Hospital/Poole Hospital and the rest of the research team on various ongoing research projects within the Bournemouth University Clinical Research Unit.

Liz Griffiths

Liz works for the Royal Bournemouth Hospital as a research facilitator.  She has been working in research within the NHS since 2003 in a variety of roles.  Currently focusing on supporting researchers to develop proposals and prepare submissions to regulatory authorities.

Louise Fazakarley

Louise is a Physiotherapy lecturer with experience in neurological rehabilitation, the management of chronic disability and rehabilitation research. She joined Bournemouth University in 2006 to establish and teach on the BSc (Hons) Physiotherapy course. Louise is currently working on the MS Society funded pilot study to look at the Nintendo Wii™ as a method of helping people with MS increase their physical activity.

Audrey Dixon

Audrey is the Centre of Postgraduate Medical Research and Education (CoPMRE) co-ordinator and co-administrator for BUCRU.  She has worked for the NHS since 1988.  She first joined Professor Paul Thompson in 2001 to assist him with his academic work, following his secondment to the university.  Audrey was seconded to BU in 2003.  She now looks after a growing Visiting Faculty of 41 members and the education arm of CoPMRE. She is very proud to see the little acorn grow into a Centre of Postgraduate Medical Research and Education and BUCRU.

Roger Baker

Roger is Professor of Clinical Psychology and runs the MSc course Foundations in Clinical Psychology at BU. He is also a Consultant Clinical Psychologist at Dorset Healthcare University NHS Foundation Trust.  He has expertise in the design of assessments and questionnaires, research design and clinical evaluation of services and has worked in a dual role as researcher and clinical psychologist at Leeds, Aberdeen & Bournemouth Universities and in NHS Trusts specialising in Mental Health.

Helen Allen

Helen is a health psychologist with a nursing and midwifery background.  She has a qualitative background with a particular interest in the mind:body interface and chronic disease, including patient empowerment.  She is the Unit lead on Public Patient Involvement.

Contact us: In the first instance please contact:

 Louise Ward (administrator):

Bournemouth University Clinical Research Unit

R505 Royal London House

Christchurch Road

Bournemouth BH1 3LT

BUCRU@bournemouth.ac.uk

Tel: 01202 961939

http://blogs.bournemouth.ac.uk/bucru/

Bournemouth University Clinical Research Unit (BUCRU)

Awarded & submitted bids, BU research, Post-award, Publishing, Research assessment, Research news

This week the Bournemouth University Clinical Research Unit (BUCRU) will be posting daily blogs. In these blogs we will tell you a little about the Unit, what we do, who we are, and how we might be able to help in your research endeavours.

What is BUCRU?  

BUCRU is a new model for supporting and conducting health related research in Dorset. It supports researchers in improving the quality, quantity and efficiency of research across the University and local National Health Service (NHS) Trusts. It does this by:

  • helping researchers with developing high quality applications for external research funding (including small grants)
  • ongoing involvement in funded research projects
  • a “pay-as-you-go” consultation service for other work

How can BUCRU help?

BUCRU can provide help in the following areas:

  • Study design
  • Quantitative and qualitative research methods
  • Statistics, data management and data analysis
  • Patient and public involvement in research
  • Trial management
  • Ethics, governance and other regulatory issues
  • Linking University and NHS researchers

BUCRU focuses on health research that has relevance to the NHS. The Unit is available to Bournemouth University staff and people working locally in the NHS. There are no general restrictions on topic area or professional background of the researcher. However we do have special interests in areas such as chronic disease and complex interventions (interventions in nursing, physiotherapy, occupational therapy, psychology and so on).

How is it funded?  

BUCRU is partly funded by the National Institute for Health Research (NIHR) and incorporates the Dorset office of the NIHR Research Design Service (http://www.rds-sw.nihr.ac.uk). Further funding comes from a variety of research grants and contracts.

Contact us: In the first instance please contact

Louise Ward (administrator):

Bournemouth University Clinical Research Unit

R505 Royal London House

Christchurch Road

Bournemouth BH1 3LT

BUCRU@bournemouth.ac.uk

Tel: 01202 961939

http://blogs.bournemouth.ac.uk/bucru/

Murphy’s Law – Anything that can go wrong will go wrong.

Post-award

The good news is that some changes to a project are commonly accepted by many sponsors and funders, providing that they don’t breach a signed contract and, most importantly, are communicated in good time. Last minute notifications can damage your and the University’s reputation, and compromise your project.

Most changes will fall under one of the following categories:  contracts, staffing, expenditure and budgets. Below you will find a list of common changes you should anticipate and communicate to your project and Research & Knowledge Transfer Operations (RKE Ops) teams as soon as they occur:

  • A project team member (Administrator, Researcher Assistant, PI, Co-I or external consultant) stops working on the project, leaves the university, is off on long term sick leave or on maternity leave;
  • A new team member joins the project;
  • The sponsor or funder asks or grants an extension to the current contract;
  • A collaborative project lead partner asks for reports or other kind of information not covered on the main contract or not requested by the sponsor or funder;
  • The sponsor or funder objects to you publishing a piece of work, and you notice that Intellectual Property issues haven’t been covered in the main contract;
  • If a contract is terminated for any reason before the end date;
  • If there are delays of any sort, for example, submission of reports, delivery of services or consultancy  work;
  • You need to spend time or money on some item or service which hasn’t been budgeted for;
  • You notice that the sponsor or funder has been inappropriately invoiced, or not invoiced  at all;
  • Your know that there have been changes to the claims schedule;
  • Your project is completed before the planned end date.

 These are only some examples of common changes that may affect your research or enterprise project and you will probably encounter many others.  Make sure you maintain good communication with your project team and seek advice from the Research & Knowledge Transfer Operations team (RKE Ops) as soon as something unexpected happens. Anything that can go wrong in a project generally does go wrong sooner or later. However, it can be put right if anticipated and properly dealt with.